MEK inhibitor GSK1120212, Purity ≥98%

Synonym: Trametinib; 871700-17-3; GSK1120212; Mekinist; GSK-1120212; JTP 74057; JTP-74057; MEK inhibitor

MDL: MFCD17215075
CAS Number: 871700-17-3
Compound CID: 11707110

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK1120212, soluble in DMSO and insoluble in ethanol and water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK1 and MEK2.

Molecular Weight

615.4

Molecular Formula

C₂₆H₂₃FIN₅O₄

Targets

MEK1: 0.92 nM; MEK2: 1.8 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 19 mg/mL (30.87 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

GSK1120212 (Trametinib) can be used to investigate the inhibition of MEK1 and MEK2 in the MAPK/ERK signaling pathway, which is often implicated in cancer.

Storage

Store at -20ºC.