MEK inhibitor MEK162, Purity ≥98%

Synonym: Binimetinib; 606143-89-9; MEK162; ARRY-162; Mektovi; ARRY-438162; MEK-162; MEK inhibitor

MDL: MFCD22124525
CAS Number: 606143-89-9
Compound CID: 10288191

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

MEK162, soluble in DMSO and insoluble in ethanol and water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK.

Molecular Weight

440

Molecular Formula

C₁₇H₁₅BrF₂N₄O₃

Targets

MEK: 12 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 86 mg/mL (194.91 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

MEK162 (Binimetinib) can be used to investigate the inhibition of MEK1/2 in the MAPK/ERK pathway for oncological research.

Storage

Store at -20ºC.