MEK inhibitor PD0325901, Purity ≥98%

Synonym: 391210-10-9; PD0325901; PD 0325901; Mirdametinib; PD-0325901; (R)-N-(2,3-Dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide; MEK inhibitor

CAS Number: 391210-10-9
Compound CID: 9826528

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PD0325901, soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK.

Molecular Weight

482.2

Molecular Formula

C₁₆H₁₄F₃IN₂O₄

Targets

MEK: 0.33 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 89 mg/mL (184.57 mM); Water: Insoluble; Ethanol: 37 mg/mL (76.73 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PD0325901 can be used to investigate the inhibition of MEK1/2 activities in cell signaling and its implications in cancer treatment.

Storage

Store at -20ºC.