MEK inhibitor PD184352 (CI-1040), Purity ≥98%

Synonym: 212631-79-3; CI-1040; PD184352; PD 184352; PD-184352; 2-(2-Chloro-4-iodophenylamino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; MEK inhibitor

MDL: MFCD02683961
CAS Number: 212631-79-3
Compound CID: 6918454

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PD184352 (CI-1040), soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK1 and MEK2.

Molecular Weight

478.7

Molecular Formula

C₁₇H₁₄ClF₂IN₂O₂

Targets

MEK1: 17 nM; MEK2: 17 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 92 mg/mL (192.19 mM); Water: Insoluble; Ethanol: 13 mg/mL (27.15 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PD184352 (CI-1040) can be used to examine the inhibition of MEK1/2 and its implications in oncogenic signaling pathways.

Storage

Store at -20ºC.