MEK inhibitor PD318088, Purity ≥98%

Synonym: PD318088; 391210-00-7; PD-318088; 5-Bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzamide; PD0318088; 5-Bromo-N-(2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodoanilino)benzamide; MEK inhibitor

CAS Number: 391210-00-7
Compound CID: 10231331

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PD318088, soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK1/2.

Molecular Weight

561.1

Molecular Formula

C₁₆H₁₃BrF₃IN₂O₄

Targets

MEK1/2

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 105 mg/mL (187.13 mM); Water: Insoluble; Ethanol: 13 mg/mL (23.17 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PD318088 can be used to investigate the inhibition of MEK1/2 in signal transduction and its effects on tumor growth.

Storage

Store at -20ºC.