MEK inhibitor RO5126766, Purity ≥98%

Synonym: 946128-88-7; RO5126766; Avutometinib; CH5126766; RO-5126766; RO-5126766 free base; Ro 5126766; MEK inhibitor

CAS Number: 946128-88-7
Compound CID: 16719221

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

RO5126766, soluble in DMSO and insoluble in ethanol and water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets BRAF V600E, B-Raf, CRAF, and MEK1.

Molecular Weight

471.5

Molecular Formula

C₂₁H₁₈FN₅O₅S

Targets

BRAF V600E; B-Raf: 19 nM; CRAF: 56 nM; MEK1: 160 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 93 mg/mL (197.26 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

RO5126766 can be used to study dual inhibition of RAF and MEK signaling pathways in cancer research.

Storage

Store at -20ºC.