MEK inhibitor SCH772984, Purity ≥98%

Synonym: SCH772984; 942183-80-4; SCH-772984; (R)-1-(2-oxo-2-(4-(4-(Pyrimidin-2-yl)phenyl)piperazin-1-yl)ethyl)-N-(3-(pyridin-4-yl)-1H-indazol-5-yl)pyrrolidine-3-carboxamide; SCH 772984; (3R)-1-[2-oxo-2-[4-[4-(2-pyrimidinyl)phenyl]-1-piperazinyl]ethyl]-N-[3-(4-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide; MEK inhibitor

MDL: MFCD11878503
CAS Number: 942183-80-4
Compound CID: 24866313

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

SCH772984, soluble in warmed DMSO and insoluble in water and ethanol, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets ERK2, ERK1, and MEK1.

Molecular Weight

587.68

Molecular Formula

C₃₃H₃₃N₉O₂

Targets

ERK2: 1 nM; ERK1: 4 nM; MEK1: >10 μM

Form

Lyophilized powder

Purity

Solubility

Warmed DMSO: 13 mg/mL (22.12 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

SCH772984 can be utilized for the inhibition of ERK1/2, studying its role in cancer cell proliferation and survival.