MEK inhibitor SL-327, Purity ≥98%

Synonym: SL327; 305350-87-2; SL-327; MEK1/2 Inhibitor; SL 327; 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile; (Z)-3-Amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile; MEK inhibitor

MDL: MFCD06411432
CAS Number: 305350-87-2
Compound CID: 9549284

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SL-327, soluble in DMSO and ethanol and insoluble in water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells.

Molecular Weight

335.4

Molecular Formula

C₁₆H₁₂F₃N₃S

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 66 mg/mL (196.81 mM); Water: Insoluble; Ethanol: 7 mg/mL (20.87 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SL-327 can be used to study the inhibition of MEK1/2 and its impact on ERK signaling in neuronal and other cellular models.

Storage

Store at -20ºC.