MEK inhibitor TAK-733, Purity ≥98%

Synonym: TAK-733; 1035555-63-5; TAK733; TAK 733; (R)-3-(2,3-Dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione; UNII-5J61HSP0QJ; MEK inhibitor

MDL: MFCD24386349
CAS Number: 1035555-63-5
Compound CID: 24963252

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TAK-733, soluble in DMSO and insoluble in ethanol and water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets MEK1.

Molecular Weight

504.2

Molecular Formula

C₁₇H₁₅F₂IN₄O₄

Targets

MEK1: 3.2 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 99 mg/mL (196.33 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

TAK-733 can be used to investigate the inhibition of MEK1/2 and its potential use in treating solid tumors.

Storage

Store at -20ºC.