MEK inhibitor U0126-EtOH, Purity ≥98%

Synonym: U0126-EtOH; 1173097-76-1; U0126 Ethanol; U0126.EtOH; (2Z,3Z)-2,3-Bis(amino(2-aminophenylthio)methylene)succinonitrile compound with ethanol (1:1); (2Z,3Z)-2,3-Bis[amino-(2-aminophenyl)sulfanylmethylidene]butanedinitrile; MEK inhibitor

CAS Number: 1173097-76-1
Compound CID: 16220066

Product Size

25 mg; 50 mg; 100 mg; 250 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

U0126-EtOH, soluble in DMSO and insoluble in ethanol and water, prevents the phosphorylation and activation of ERK leading to reduced cell proliferation and induced apoptosis in cancerous cells. It targets Abl, CDK2, and CDK4.

Molecular Weight

426.6

Molecular Formula

C₁₈H₁₆N₆S₂.C₂H₆O

Targets

Abl: 100 μM; CDK2: 10 μM; CDK4: 10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 77 mg/mL (180.51 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

U0126-EtOH can be used to study the inhibition of MEK1/2 and its downstream effects on ERK phosphorylation in signal transduction pathways.