Metabolic Pathway-based Cell Surface Glycoengineering Service

Metabolic Pathway-based Cell Surface Glycoengineering (MP-CSGE) in Disease Research

MP-CSGE is to achieve targeted alteration of cell surface glycan structure by modulating enzyme activities or substrate concentrations associated with glycan modification in intracellular metabolic pathways. It alters the glycan structure on the cell surface and thus reveals the association between changes in glycan structure and disease. This is essential for understanding the pathogenesis of diseases, searching for new targets, and developing drugs. Moreover, it can be used for targeted modification of glycan modification on the surface of tumor cells or pathogens to enhance the attack ability of immune cells. This provides new ideas and strategies for antitumor vaccine research. In addition, the metabolism, distribution, and potency of drugs can be modulated which is of great significance in promoting disease research and pharmaceutical research.

Fig.1 Metabolic glycoengineering (MGE)-enabled design of antibody-drug conjugates. (Agatemor, et al., 2019)

MP-CSGE Service at CD BioGlyco

CD BioGlyco provides efficient CSGE services with the most professional Glycoengineering Platform. Moreover, our CSGE services based on metabolic pathways, Chemical Conjugation, Liposome Fusion, and Genetic Methods are well received by our clients. The specifics of our MP-CSGE services are as follows:

Applications

• These technologies provide the field of biocatalysis and enzyme engineering with new tools and platforms for the production of specific glycoproducts and drugs.
• MP-CSGE can be used for targeted modification of cell surface glycan modification structures, thereby altering the interactions between cells and other biomolecules.
• By modulating metabolic pathways and substrate availability, specific glycan structures can be introduced at the cell surface, thereby increasing drug selectivity and efficacy and reducing side effects.

Advantages of Us

• We use state-of-the-art technologies to perform glycan modification directly on the cell surface, which greatly improves efficiency.
• We have established a complete platform covering all aspects of technologies, including key aspects such as metabolic pathway regulation, substrate supply, and optimization of modification reactions.

CD BioGlyco is a biotechnology company that possesses significant expertise in the development of products and services about glycobiology. Our primary focus is to propel the progress of glycan-based drugs, and we offer a comprehensive range of services known as MP-CSGE services to our clientele. If you need the related services mentioned above, please feel free to contact us directly for more details.