Description
Methiothepin mesylate inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets 5-HT1A receptor, 5-HT1B receptor, 5-HT1C receptor, 5-HT1D receptor, 5-HT2A receptor, 5-HT2B receptor, 5-HT2C receptor, 5-HT5A receptor, 5-HT5B receptor, 5-HT6 receptor, and 5-HT7 receptor.
Targets
5-HT1A receptor: 7.10 (pKd); 5-HT1B receptor: 7.28 (pKd); 5-HT1C receptor: 7.56 (pKd); 5-HT1D receptor: 6.99 (pKd); 5-HT2A receptor: 8.50 (pKi); 5-HT2B receptor: 8.68 (pKi); 5-HT2C receptor: 8.35 (pKi); 5-HT5A receptor: 7.0 (pKd); 5-HT5B receptor: 7.8 (pKd); 5-HT6 receptor: 8.74 (pKd); 5-HT7 receptor: 8.99 (pKd)
