Rigorous Metronidazole and Glucose Injection Analysis and Proficiency Business

CD BioGlyco has developed a wide range of Pharmaceutical and Biological Analysis Services. The scope of these Pharmaceutical Analyses covers a wide range of drugs including metronidazole and glucose injection, Gadobenate Dimeglumine Injection, Voglibose, etc. Metronidazole and glucose injections are used to fight infections caused by sensitive bacteria, especially anaerobes. Its analysis not only lays the foundation for quality control and process optimization during its production, etc. but also provides the basis for the research of therapeutic mechanisms. We provide a one-stop analytical service for metronidazole and glucose injection to assist our clients in their research.

Metronidazole and glucose injection-related tests are listed below:

• Character observation
  The injection is a colorless to slightly yellow clear liquid.
• Identification
  We identify it by ultraviolet-visible (UV-Vis) spectrophotometry and high-performance liquid chromatography (HPLC).
• pH value detection
  The pH value of metronidazole and glucose injection should be 4.5~6.0.
• Determination of nitrite content
  Nitrite content is determined by ion chromatography (5 mmol/L potassium hydroxide solution as eluent). Sodium nitrite is used as the control, and the content of nitrite in the test material is calculated by peak area. The content of nitrite should not exceed 0.8% of the labeled amount of metronidazole.
• Detection of relevant substances
  HPLC with light protection is used to detect a wide range of substances.
• 5-Hydroxymethylfurfural assay
  We take the appropriate amount of 5-hydroxymethylfurfural control product and configure it into the control solution. After that, we inject the test and control solution into the liquid chromatograph, record the chromatogram, and calculate the content of 5-hydroxymethylfurfural according to the peak area.
• Osmotic pressure molar concentration
  The osmotic pressure molar concentration of the test product is checked. The osmotic pressure molar concentration ratio should be 0.9~1.1.
• Heavy metals
  We take an appropriate amount of the test material and place it in a water bath to evaporate. After cooling, we add acetate buffer and water to a certain amount and test the heavy metal content.
• Others: Harmful element residue test, endotoxin test, insoluble particle test, sterility test, etc.
• Determination of content
  
  • Glucose: We measure the optical rotation of the test material, and the content of glucose is calculated.
  • Metronidazole: We measure the content of metronidazole by HPLC using methanol-water as the mobile phase.

Fig.1 Process of metronidazole and glucose injection analysis. (CD BioGlyco)

Publication Data

Applications

• The metronidazole and glucose injection analysis is used for quality control and process optimization studies during the manufacture of the injection.
• The metronidazole and glucose injection analysis provides data support for the study and analysis of the therapeutic mechanism of the injection.
• The metronidazole and glucose injection analysis plays an important role in studying the effect of light, pH, and other factors on the stability of this injection.

Advantages of Us

• We have professional analysis systems, complete testing procedures, and rigorous quality control management for metronidazole and glucose injection analysis projects, which greatly shorten the analysis cycle.
• Our metronidazole and glucose injection analytical program covers a comprehensive range.
• Our HPLC method is sensitive, stable, and fast, with excellent reproducibility and good peak shapes.

CD BioGlyco has experts with rich experience in R&D and management and possesses many analytical approaches. We have a unified quality assurance system and provide high-quality analytical reports. Please feel free to contact us for more information about metronidazole and glucose injection analysis if you need this area.