Microtubule/Tubulin inhibitor, Monomethyl auristatin E, Purity ≥98%

Synonym: 474645-27-7; Monomethylauristatin E; MMAE; Monomethyl auristatin E (GMP); SGD-1010; (2S)-N-[(2S)-1-[[(3R,4S,5S)-1-[(2S)-2-[(1R,2R)-3-[[(1S,2R)-1-Hydroxy-1-phenylpropan-2-yl]amino]-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl]-3-methoxy-5-methyl-1-oxoheptan-4-yl]-methylamino]-3-methyl-1-oxobutan-2-yl]-3-methyl-2-(methylamino)butanamide

MDL: MFCD22124498
CAS Number: 474645-27-7
Compound CID: 11542188

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Monomethyl auristatin E, soluble in DMSO and ethanol and insoluble in water, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting microtubule/tubulin.

Molecular Weight

717.98

Molecular Formula

C₃₉H₆₇N₅O₇

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 93 mg/mL (129.52 mM); Water: insoluble; Ethanol: 93 mg/mL (129.52 mM)

Applications

Monomethyl auristatin E is a cytoskeletal signaling inhibitor that can be used for its ability to deliver cytotoxic drugs directly to cancer cells, minimizing off-target effects and improving therapeutic efficacy.