Properties
Description
Nocodazole, soluble in DMSO and insoluble in water and ethanol, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting microtubule/tubulin. It targets the Abl (cell-free assay), Abl (E255K) (cell-free assay), Abl (T315I) (cell-free assay), and microtubules (cell-free assay).
Molecular Formula
C14H11N3O3S
Targets
Abl (Cell-free assay): 0.21 μM; Abl (E255K) (Cell-free assay): 0.53 μM; Abl (T315I) (Cell-free assay): 0.64 μM; Microtubules (Cell-free assay)
Titer
Free from inappropriate visible particulates, foreign matter, discoloration, or other defects
Solubility
In vitro: DMSO: 6 mg/mL (19.91 mM); Water: insoluble; Ethanol: insoluble; In vivo: 2% DMSO + 30% PEG 300 + 2% Tween 80 + ddH2O, 1 mg/mL
Stability
In its lyophilized form, the chemical remains stable for 36 months.
Quality Level
Research grade
Applications
Nocodazole is a cytoskeletal signaling inhibitor that plays a key role in the study of microtubule dynamics and the cell cycle.
Storage
Store at -20ºC, and keep desiccated.
