Microtubule/Tubulin inhibitor, Nocodazole, Purity ≥98%

Synonym: 31430-18-9; Oncodazole; R 17934; Nocodazol; Nocodazolum; Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate; Methyl (5-(thiophene-2-carbonyl)-1H-benzo[d]imidazol-2-yl)carbamate; Methyl N-[6-(thiophene-2-carbonyl)-1H-benzimidazol-2-yl]carbamate

MDL: MFCD00005588
CAS Number: 31430-18-9
Compound CID: 4122

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Nocodazole, soluble in DMSO and insoluble in water and ethanol, is an effective cytoskeleton inhibitor, that has the ability to prevent the pathway of cytoskeletal signaling by inhibiting microtubule/tubulin. It targets the Abl (cell-free assay), Abl (E255K) (cell-free assay), Abl (T315I) (cell-free assay), and microtubules (cell-free assay).

Molecular Weight

301.32

Molecular Formula

C₁₄H₁₁N₃O₃S

Targets

Abl (Cell-free assay): 0.21 μM; Abl (E255K) (Cell-free assay): 0.53 μM; Abl (T315I) (Cell-free assay): 0.64 μM; Microtubules (Cell-free assay)

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 6 mg/mL (19.91 mM); Water: insoluble; Ethanol: insoluble; In vivo: 2% DMSO + 30% PEG 300 + 2% Tween 80 + ddH₂O, 1 mg/mL

Applications

Nocodazole is a cytoskeletal signaling inhibitor that plays a key role in the study of microtubule dynamics and the cell cycle.