Properties
Description
ML347, soluble in DMSO and insoluble in water and ethanol, blocks the function of Smad proteins in the TGF-β signaling pathway. It targets ALK1, ALK2, ALK3, and ALK6.
Molecular Formula
C22H16N4O
Targets
ALK1: 46 nM; ALK2: 32 nM; ALK3: 10.8 μM; ALK6: 9.83 μM
Solubility
DMSO: 9 mg/mL (25.53 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
ML347 can be used as a selective agonist of the melanocortin 1 receptor (MC1R).
Storage
Store at -20℃, and keep desiccated.