MLK inhibitor URMC-099, Purity ≥98%

Synonym: URMC-099; 1229582-33-5; 3-(1H-indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine; CHEMBL2436978; 3-(1H-indol-5-yl)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridine; 5-(5-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-3-yl)-1H-indole; MLK inhibitor

MDL: MFCD28168077
CAS Number: 1229582-33-5
Compound CID: 54764565

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

URMC-099, soluble in DMSO and ethanol and insoluble in water, is a potent and selective MLK inhibitor. It targets LRRK2, MLK3, Abl1, and AMPK.

Molecular Weight

421.54

Molecular Formula

C₂₇H₂₇N₅

Targets

LRRK2: 11 nM; MLK3: 14 nM; Abl1: 6.5 nM; AMPK: 1512 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 76 mg/mL (180.28 mM); Water: Insoluble; Ethanol: 5 mg/mL (11.86 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

URMC-099 can be investigated for its anti-inflammatory properties and inhibition of mixed lineage kinase 3 (MLK3) in neuroinflammation models.

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