MMP inhibitor GM 6001, Purity ≥98%

Synonym: 142880-36-2; MMP inhibitor; Galardin; Ilomastat; GM-6001

MDL: MFCD00917040
CAS Number: 142880-36-2
Compound CID: 132519

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GM 6001, soluble in DMSO and warmed ethanol and insoluble in water, inhibits MMPs, enzymes that degrade extracellular matrix components, thus having potential therapeutic applications in cancer and chronic inflammatory diseases. It targets MMP-26, MMP-9, MMP-1, MMP-12, MMP-14, MMP-2, MMP-3, MMP-7, and MMP-8.

Molecular Weight

388.5

Molecular Formula

C₂₀H₂₈N₄O₄

Targets

MMP-26: 0.36 nM (Ki); MMP-9: 0.2 nM (Ki); MMP-1: 0.4 nM (Ki); MMP-12: 3.6 nM (Ki); MMP-14: 13.4 nM (Ki); MMP-2: 0.5 nM (Ki); MMP-3: 27 nM (Ki); MMP-7: 3.7 nM (Ki); MMP-8: 0.1 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 73 mg/mL (187.92 mM); Water: Insoluble; Warmed ethanol: 7 mg/mL (18.02 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

GM 6001 is an MMP inhibitor used to explore the inhibition of matrix metalloproteinases, significant in cancer metastasis and arthritis research.