CD BioGlyco provides a monosaccharide-based biodegradable material development service to meet specific material development and application needs. Our service is used for a wide range of biomedical, food packaging, agricultural applications, etc., and includes polymer design and synthesis, polymer processing, material preparation, analysis, and characterization. With our extensive knowledge and experience in the Development of Carbohydrate-based Biodegradable Materials, we have prepared a variety of biodegradable materials such as hydrogels. The biodegradable material development process is as follows:
We mainly use two development strategies to prepare monosaccharide-based biodegradable materials.
Our goal is to develop materials with good biocompatibility, mechanical strength, biodegradability, and non-toxic degradation products. When designing polymers, we look at the polymer chain end groups, monomers, and their respective ratios, etc., to meet the exact needs and goals of our clients.
We analyze materials in a comprehensive and detailed manner through biodegradability testing and physical, chemical, and biological characterization.
Fig.1 Flowchart of monosaccharide-based biodegradable material development. (CD BioGlyco)
Technology: Photopolymerisation
Journal: Materials
IF: 3.4
Published: 2022
Results: In this study, two glucose monomer derivatives 2,3,4,6 tetra-O-acetyl-1-acryloylglucopyranose (AGlc) and 2,3,4,6-tetra-O-acetyl-1 methacryloyl-glucopyranose (MGlc) were synthesized. Then homopolymers were prepared by polymerization of these two monomer derivatives by photopolymerisation. The properties of the homopolymers were examined and the results showed that the homopolymers of AGlc and MGlc had good heat resistance and transparency and were biodegradable. This study provides an effective strategy for the development of biodegradable materials based on monosaccharides.
Fig.2 Synthesis of new derivatives of glucose: AGlc and MGlc. (Gawdzik, et al., 2022)
There are many factors that affect biodegradable properties. The chemical properties of the polymers including surface morphology, molecular weight, distribution, chemical structure, crystallinity, etc., all affect the material properties. The effect of these factors on the mechanical properties, biodegradability, and biocompatibility of the material should be considered during the design and preparation process.
The material must have a porous network that is biocompatible, biodegradable, and mechanically strong. It also needs to contain biochemical cues or surface chemistry for cell attachment, nutrient and waste movement, structural support, and promotion of cell proliferation and differentiation. In addition, the material must be non-toxic in terms of the substances produced during degradation.
CD BioGlyco is the preferred provider of monosaccharide-based biodegradable material solutions. We support and assist our clients throughout the entire cycle from early material design and preparation to analysis. Welcome to contact us with your needs and requirements if you are interested in our monosaccharide-based biodegradable materials development services. Our research team will be the first to contact you.
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