MTH1 inhibitor, (S)-Crizotinib, Purity ≥98%

Synonym: 1374356-45-2; Ent-crizotinib; 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yi)pyridin-2-amine; 3-[(1S)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

CAS Number: 1374356-45-2
Compound CID: 56671814

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

(S)-Crizotinib, soluble in warmed DMSO and ethanol and insoluble in water, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of DNA damage by inhibiting MTH1. It targets the MTH1 (cell-free assay).

Molecular Weight

450.34

Molecular Formula

C₂₁H₂₂Cl₂FN₅O

Targets

MTH1 (Cell-free assay): 72 nM

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO (warmed): 42 mg/mL (93.26 mM); Water: insoluble; Ethanol: 22 mg/mL (48.85 mM)

Applications

(S)-Crizotinib is a DNA damage inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of non-small cell lung cancer (NSCLC) and other cancers with ALK (anaplastic lymphoma kinase) or ROS1 (c-ros oncogene 1) gene rearrangements.