MTH1 inhibitor, TH287, Purity ≥98%

Synonym: 1609960-30-6; TH-287; TH 287; 6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine; 6-(2,3-dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine; 6-(2,3-Dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine

MDL: MFCD29035111
CAS Number: 1609960-30-6
Compound CID: 73441664

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TH287, soluble in DMSO and warmed ethanol and insoluble in water, is an effective DNA damage inhibitor, that has the ability to prevent the pathway of DNA damage by inhibiting MTH1. It targets the MTH1 (NUDT1).

Molecular Weight

269.13

Molecular Formula

C₁₁H₁₀Cl₂N₄

Targets

MTH1 (NUDT1): 0.8 nM

Form

Lyophilized powder

Purity

≥98%

Titer

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects

Solubility

In vitro: DMSO: 48 mg/mL (178.35 mM); Water: insoluble; Ethanol (warmed): 9 mg/mL (33.44 mM)

Applications

TH287 is a DNA damage inhibitor that can be studied extensively for its potential therapeutic applications in the treatment of lysosomal storage diseases.