Properties
Description
AZD2014, soluble in DMSO and insoluble in ethanol and water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets mTOR, P-Akt (S473), and pS6 (S235/236).
Molecular Formula
C25H30N6O3
Targets
mTOR: 2.8 nM; P-Akt (S473): 80 nM; pS6 (S235/236): 200 nM
Solubility
DMSO: 32 mg/mL (69.18 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
AZD2014 can be used to examine the dual inhibition of mTORC1 and mTORC2 pathways in cancer research.
