Properties
Description
AZD8055, soluble in warmed DMSO and ethanol and insoluble in water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets DNA-PK, mTOR(fulllength), ATM, mTOR (truncated), PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.
Molecular Formula
C25H31N5O4
Targets
DNA-PK: 1370 nM; mTOR(fulllength): 0.8 nM; ATM: 1370 nM; mTOR (truncated): 0.13 nM; PI3Kα: 3590 nM; PI3Kβ: 18900 nM; PI3Kδ: 3200 nM; PI3Kγ: >14790 nM
Solubility
Warmed DMSO: 49 mg/mL (105.25 mM); Water: Insoluble; Ethanol: 3 mg/mL (6.44 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
AZD8055 can be used to study the inhibition of both mTORC1 and mTORC2 in various cellular processes, including cancer progression.
