mTOR inhibitor AZD8055, Purity ≥98%

Synonym: 1009298-09-2; AZD-8055; AZD 8055; (5-(2,4-Bis((S)-3-methylmorpholino)pyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol; mTOR inhibitor

CAS Number: 1009298-09-2
Compound CID: 25262965

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD8055, soluble in warmed DMSO and ethanol and insoluble in water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets DNA-PK, mTOR(fulllength), ATM, mTOR (truncated), PI3Kα, PI3Kβ, PI3Kδ, and PI3Kγ.

Molecular Weight

465.5

Molecular Formula

C₂₅H₃₁N₅O₄

Targets

DNA-PK: 1370 nM; mTOR(fulllength): 0.8 nM; ATM: 1370 nM; mTOR (truncated): 0.13 nM; PI3Kα: 3590 nM; PI3Kβ: 18900 nM; PI3Kδ: 3200 nM; PI3Kγ: >14790 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 49 mg/mL (105.25 mM); Water: Insoluble; Ethanol: 3 mg/mL (6.44 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD8055 can be used to study the inhibition of both mTORC1 and mTORC2 in various cellular processes, including cancer progression.