Properties
Description
CC-223, soluble in DMSO and ethanol and insoluble in water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets cFMS, DNA-PK, FLT4, mTOR, and PI3Kα.
Molecular Formula
C21H27N5O3
Targets
cFMS: 28 nM; DNA-PK: 840 nM; FLT4: 651 nM; mTOR: 16 nM; PI3Kα: 4 nM
Solubility
DMSO: 70 mg/mL (176.11 mM); Water: Insoluble; Ethanol: 70 mg/mL
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CC-223 can be used to explore its role as an mTORC1 and mTORC2 inhibitor in cancer and other proliferative diseases.
