mTOR inhibitor INK 128, Purity ≥98%

Synonym: 1224844-38-5; INK128; INK-128; MLN0128; mTOR inhibitor

CAS Number: 1224844-38-5
Compound CID: 45375953

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

INK 128, soluble in DMSO and ethanol and insoluble in water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets mTOR, PI3Kα, mTOR, PI3Kβ, PI3Kδ, and PI3Kγ.

Molecular Weight

309.3

Molecular Formula

C₁₅H₁₅N₇O

Targets

mTOR: 1.4 nM (Ki); PI3Kα: 219 nM; mTOR: 1.4 nM (Ki); PI3Kβ: 5293 nM; PI3Kδ: 230 nM; PI3Kγ: 221 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 58 mg/mL (187.5 mM); Water: Insoluble; Ethanol: 2 mg/mL (6.46 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

INK 128 can be used to study its role as an mTORC1 and mTORC2 inhibitor in cancer and other diseases.