mTOR inhibitor OSI-027, Purity ≥98%

Synonym: 936890-98-1; OSI027; mTOR inhibitor

CAS Number: 936890-98-1
Compound CID: 135398516

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

OSI-027, soluble in DMSO and insoluble in ethanol and water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets mTORC1, mTORC2, ACK1, BTK, C-Raf, DNA-PK, EGFR/ErbB1, EphA2, Fyn, IGF-1R, and insulin receptor.

Molecular Weight

406.4

Molecular Formula

C₂₁H₂₂N₆O₃

Targets

mTORC1: 22 nM; mTORC2: 65 nM; ACK1: >10 μM; BTK: 5.0 μM; C-Raf: 1.6 μM; DNA-PK: 1.0 μM; EGFR/ErbB1: >30 μM; EphA2: 4.5 μM; Fyn: >30 μM; IGF-1R: >30 μM; InsulinReceptor: >30 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 16 mg/mL (39.36 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

OSI-027 can be employed to investigate dual mTORC1 and mTORC2 inhibition in oncology research.

Storage

Store at -20ºC.