mTOR inhibitor PP242, Purity ≥98%

Synonym: 1092351-67-1; PP-242; Torkinib; mTOR inhibitor

CAS Number: 1092351-67-1
Compound CID: 135565635

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

PP242, soluble in DMSO and ethanol and insoluble in water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets DNA-PK, p110δ, Abl, EGFR, EphB4, Hck, mTOR, p110α, p110β, p110γ, and PDGFR.

Molecular Weight

308.3

Molecular Formula

C₁₆H₁₆N₆O

Targets

DNA-PK: 0.41 μM; p110δ: 0.10 μM; Abl: 3.6 μM; EGFR: 4.4 μM; EphB4: 3.4 μM; Hck: 1.2 μM; mTOR: 8 μM; p110α: 2.0 μM; p110β: 2.2 μM; p110γ: 1.3 μM; PDGFR: 0.41 μM

Form

Lyophilized powder

Purity

Solubility

DMSO: 57 mg/mL (184.86 mM); Water: Insoluble; Ethanol: 17 mg/mL (55.13 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

PP242 is utilized in studies examining the inhibition of mTORC1 and mTORC2 in cellular growth and cancer.