mTOR inhibitor PP242, Purity ≥98%

Synonym: 1092351-67-1; PP-242; Torkinib; mTOR inhibitor

CAS Number: 1092351-67-1
Compound CID: 135565635

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PP242, soluble in DMSO and ethanol and insoluble in water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets DNA-PK, p110δ, Abl, EGFR, EphB4, Hck, mTOR, p110α, p110β, p110γ, and PDGFR.

Molecular Weight

308.3

Molecular Formula

C₁₆H₁₆N₆O

Targets

DNA-PK: 0.41 μM; p110δ: 0.10 μM; Abl: 3.6 μM; EGFR: 4.4 μM; EphB4: 3.4 μM; Hck: 1.2 μM; mTOR: 8 μM; p110α: 2.0 μM; p110β: 2.2 μM; p110γ: 1.3 μM; PDGFR: 0.41 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 57 mg/mL (184.86 mM); Water: Insoluble; Ethanol: 17 mg/mL (55.13 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PP242 is utilized in studies examining the inhibition of mTORC1 and mTORC2 in cellular growth and cancer.

Storage

Store at -20ºC.