mTOR inhibitor Torin 1, Purity ≥98%

Synonym: 1222998-36-8; Torin1; mTOR inhibitor

CAS Number: 1222998-36-8
Compound CID: 49836027

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Torin 1, soluble in DMSO and insoluble in ethanol and water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets DNA-PK, mTOR, C2α, C2β, hVPS34, mTORC1, mTORC2, p110α/p85α, p110δ/p85α, p110γ, and PI4Kα.

Molecular Weight

607.62

Molecular Formula

C₃₅H₂₈F₃N₅O₂

Targets

DNA-PK: 6.34 nM; mTOR: 4.32 nM; C2α: 176 nM; C2β: 549 nM; hVPS34: 533 nM; mTORC1: 2 nM; mTORC2: 10 nM; p110α/p85α: 250 nM; p110δ/p85α: 564 nM; p110γ: 171 nM; PI4Kα: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 2 mg/mL (3.29 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Torin 1 can be employed to study the effects of mTOR inhibition on cellular growth and autophagy.

Storage

Store at -20ºC.