Properties
Description
Torin 2, soluble in DMSO and insoluble in ethanol and water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets ATM (PC3 cells), ATR (PC3 cells), DNA-PK (PC3 cells), and mTOR.
Molecular Formula
C24H15F3N4O
Targets
ATM (PC3 cells): 28 nM (EC50); ATR (PC3 cells): 35 nM (EC50); DNA-PK (PC3 cells): 118 nM (EC50); mTOR: 0.25 nM (EC50)
Solubility
DMSO: 18 mg/mL (41.63 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Torin 2 is used to research selective inhibition of mTORC1 and mTORC2 in various cellular processes.
