mTOR inhibitor WYE-687, Purity ≥98%

Synonym: 1062161-90-3; WYE687; mTOR inhibitor

CAS Number: 1062161-90-3
Compound CID: 25229450

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

WYE-687, soluble in DMSO and insoluble in ethanol and water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets PI3Kα, PI3Kγ, Abl1, AuroraB, CDK1/CyclinB, CDK2/CyclinA, Chk1, ERK2, Fyn, GCK, and Hck.

Molecular Weight

528.61

Molecular Formula

C₂₈H₃₂N₈O₃

Targets

PI3Kα: 0.81 μM; PI3Kγ: 3.11 μM; Abl1: >50 μM; AuroraB: >50 μM; CDK1/CyclinB: >50 μM; CDK2/CyclinA: >50 μM; Chk1: >50 μM; ERK2: >50 μM; Fyn: >50 μM; GCK: >50 μM; Hck: >50 μM

Form

Lyophilized powder

Purity

Solubility

DMSO: 0.45 mg/mL (0.85 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

WYE-687 is employed in scientific studies as an mTOR kinase inhibitor to explore the mTOR signaling cascade and its implications in cancer and metabolic diseases.