mTOR inhibitor XL388, Purity ≥98%

Synonym: 1251156-08-7; XL 388; XL-388; mTOR inhibitor

CAS Number: 1251156-08-7
Compound CID: 59604787

Product Size

5 mg; 10mg; 25 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

XL388, soluble in DMSO and insoluble in ethanol and water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets mTOR, mTORC2, CYP2C8, CYP2C9, CYP2D6, CYP3A4, mTORC1, and PI3Kα.

Molecular Weight

455.5

Molecular Formula

C₂₃H₂₂FN₃O₄S

Targets

mTOR: 9.9 nM; mTORC2: 166 nM; CYP2C8: >20 μM; CYP2C9: 10.6 μM; CYP2D6: >20 μM; CYP3A4: 24.6 μM; mTORC1: 8 nM; PI3Kα: >3 μM

Form

Lyophilized powder

Purity

Solubility

DMSO: 21 mg/mL (46.1 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

XL388 is used to study the inhibition of mTOR kinase and its effects on cell growth, proliferation, and survival, particularly in cancerous cells.