Properties
Description
XL388, soluble in DMSO and insoluble in ethanol and water, disrupts cell growth, proliferation, and survival by targeting a key component of cellular signaling pathways. It targets mTOR, mTORC2, CYP2C8, CYP2C9, CYP2D6, CYP3A4, mTORC1, and PI3Kα.
Molecular Formula
C23H22FN3O4S
Targets
mTOR: 9.9 nM; mTORC2: 166 nM; CYP2C8: >20 μM; CYP2C9: 10.6 μM; CYP2D6: >20 μM; CYP3A4: 24.6 μM; mTORC1: 8 nM; PI3Kα: >3 μM
Solubility
DMSO: 21 mg/mL (46.1 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
XL388 is used to study the inhibition of mTOR kinase and its effects on cell growth, proliferation, and survival, particularly in cancerous cells.
