NADPH oxidase inhibitor GKT137831, Purity ≥98%

Synonym: 1218942-37-0; GKT137831; Setanaxib; GKT-137831; 2-(2-Chlorophenyl)-4-(3-(dimethylamino)phenyl)-5-methyl-1H-pyrazolo[4,3-c]pyridine-3,6(2H,5H)-dione; NADPH oxidase inhibitor

MDL: MFCD27923122
CAS Number: 1218942-37-0
Compound CID: 58496428

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GKT137831, soluble in warmed DMSO and insoluble in water and ethanol, is a NADPH oxidase inhibitor. It targets NOX1 and NOX4.

Molecular Weight

394.85

Molecular Formula

C₂₁H₁₉ClN₄O₂

Targets

NOX1: 110 nM (Ki); NOX4: 140 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 72 mg/mL (182.34 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GKT137831 can be used to study its selective inhibition of NOX1/4 in fibrosis and vascular diseases.