Properties
Description
Naftopidil (flivas), soluble in DMSO and insoluble in water and ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins. It targets α1A-adrenergic receptor, α1B-adrenergic receptor, and α1D-adrenergic receptor.
Molecular Formula
C24H28N2O3
Targets
α1A-adrenergic receptor: 3.7 nM (Ki); α1B-adrenergic receptor: 20 nM (Ki); α1D-adrenergic receptor: 1.2 nM (Ki)
Solubility
DMSO: 77 mg/mL (196.17 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Naftopidil (flivas) can be used for its effect on relaxing the smooth muscle in the prostate gland and the bladder neck.
Storage
Store at -20℃, and keep desiccated.
