Properties
Description
Nepicastat (free base) (SYN-117), soluble in DMSO and insoluble in water and ethanol, inhibits the signaling pathway between G-protein-coupled receptors (GPCRs) and G proteins.
Molecular Formula
C14H15F2N3S
Solubility
DMSO: 61 mg/mL (183.83 mM); Water: insoluble; Ethanol: insoluble
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Nepicastat (free base) (SYN-117) can be used its effect on inhibiting the enzyme dopamine β-hydroxylase (DBH), which is involved in the conversion of dopamine to norepinephrine.
Storage
Store at -20℃, and keep desiccated.
