Features of Guanine

Guanine is an organic compound consisting of a system of thickened pyrimidine-imidazole rings with conjugated double bonds, with the chemical formula C₅H₅N₅O. Guanine is a purine derivative, a white to yellowish crystalline powder with strong UV absorption, and a component of guanosine and guanosine acid. It is used in the manufacture and marketing of guanine derivatives. It is also one of the basic components of nucleic acids (DNA and RNA). Guanine is widely found in the animal and plant kingdoms. As a special substance, it has been successfully used in the preparation of anti-herpes medications such as acyclovir and pamprovaler ointment. In addition, guanine plays an important role in energy supply and metabolic regulation and also forms coenzymes.

Fig.1 Biogenic guanine crystal. (Pinsk, et al., 2022)

Nucleoside-based Guanine Production Service at CD BioGlyco

Analyzing guanine from the point of view of the nature of the substance, it can be found that it is an organic compound of the purine class, which consists mainly of an imidazole ring and a pyrimidine ring. Therefore, when synthesizing guanine, CD BioGlyco offers several chemical synthesis routes.

• One-step synthesis
  CD BioGlyco synthesized guanine in one step by dehydration reaction catalyzed by a catalyst using pyrimidine derivatives and amide organic compounds as substrates. The method is highly efficient and environmentally friendly, and the purity of the obtained guanine is high, with a yield of up to 95%.
• Stepwise synthesis
  The second chemical method offered by CD BioGlyco involves the production of guanine from ester compounds as a starting material with inorganic salts through condensation, nitrosation, reduction, and cyclization reactions. This method is capable of producing large quantities of guanine at a time and in high yields.

In addition to the production of guanine, CD BioGlyco provides guanine application services. For example, the guanine we produce could be used as a raw material in research on antiviral drugs and antitumor drugs.

Fig.2 Flow chart of guanine production service. (CD BioGlyco)

Applications

• Guanine could be used in the development of cardio-protective drug production.
• Guanine could be used in the development of anti-inflammatory drug production.
• Guanine could be used as a raw material for the treatment of human herpes virus.
• The production of guanine contributes to the study of its structure and function.
• The production of guanine helps to study the structure and function of nucleosides.

As a leading provider of a wide range of custom syntheses, CD BioGlyco has extensive experience in the synthesis of guanines. We are confident that we offer a comprehensive range of custom synthesis services to meet the specific needs of our clients in guanine synthesis for research and project development. If you are interested in our synthesis services, please feel free to contact us directly.