Characterization of Nucleosides

Nucleosides are widely found in nature and they are closely related to life activities. The use of nucleosides is highly specialized, and they are indispensable raw materials in biomedical research, as well as basic elements in the preparation of biological products. For example, nucleosides are widely used as antitumors, antiviral small molecule drugs, and nucleic acid drugs. Meanwhile, nucleoside derivatives are also vital raw materials for gene sequencing kits. Modification of nucleoside bases or sugar rings is a common strategy to enhance the pharmacokinetic and pharmacodynamic properties of nucleoside molecules, reduce the immunogenicity of nucleic acid drugs, and improve their stability. In addition, nucleosides have important applications in molecular biology, gene cloning, and DNA microarrays. Thus, nucleosides are expected to be the next generation of drugs with important roles after sulfonamides and antibiotics. Based on the numerous advantages of nucleosides, a comprehensive production study of nucleosides is necessary.

Fig.1 Structure of nucleoside analogs. (Wikipedia)

Nucleoside Chemical Synthesis Service at CD BioGlyco

There are numerous routes for the production of nucleosides, of which chemical methods are already a well-established synthetic route. At CD BioGlyco, we offer a full range of chemical synthesis services. Specifically, we offer chemical production services including, but not limited to:

• Total synthesis of nucleosides
• Backbone synthesis of nucleosides
• Derivative synthesis of nucleosides
• Chemical modification of nucleosides

During the chemical synthesis process, we provide microwaves to improve the efficiency of the synthesis.

In addition to nucleoside synthesis services, we also provide product analysis services. Specific services include, but are not limited to, structural characterization of the products (NMR hydrogen spectroscopy, liquid-mass spectrometry, high-performance liquid chromatography, XRD, etc.) and performance testing (thermogravimetric analysis, etc.).

Fig.2 Chemical synthesis of nucleoside content. (CD BioGlyco)

Applications

• Nucleosides are used as pharmaceutical intermediates and as raw materials for the production of food additives.
• In industry, nucleosides are used in the development of cosmetics that are resistant to ultraviolet radiation.
• In the medical field, nucleosides are used in the development of anti-tumor and anti-viral drugs.

Advantages

• Our nucleoside synthesis services help to explore the physiological functions of nucleosides in depth.
• Nucleoside synthesis contributes to the development of antiviral drugs.

CD BioGlyco has a dedicated and experienced nucleoside research team. We have successfully developed a range of chemical routes for the production of nucleoside analogs, enabling rapid and efficient synthesis of modified nucleoside analogs and their derivatives. Our services are capable of meeting the needs of nucleoside analogs from early stage to preclinical development. If you are interested in our services, please feel free to contact us.