O-glycans play a key role in cell-to-cell signaling, protein structure stabilization, immune regulation, and more, making them an ideal entry point for studying biological systems. At CD BioGlyco, we use advanced synthesis and purification methods to provide clients with worry-free O-glycan products. We ensure that each product has high purity and accuracy, providing researchers with reliable tools. We also focus on in-depth collaboration with clients to develop customized products that meet specific research needs and turn clients' innovative ideas into viable solutions.
O-glycans Structure
Depending on the initial sugar group and the sugar chain extension method, O-glycans are mainly divided into eight core structures:
- Core type 1 O-glycan: Galβ1-3GalNAcα1-Ser/Thr
- Core type 2 O-glycan: GlcNAcβ1-6[Galβ1-3]GalNAcα1-Ser/Thr
- Core type 3 O-glycan: GlcNAcβ1-3GalNAcα1-Ser/Thr
- Core type 4 O-glycan: GlcNAcβ1-6[GlcNAcβ1-3]GalNAcα1-Ser/Thr
- Core type 5 O-glycan: GalNAcα1-Ser/Thr
- Core type 6 O-glycan: GlcNAcβ1-6GalNAcα1-Ser/Thr
- Core type 7 O-glycan: Galβ1-3GlcNAcβ1-3GalNAcα1-Ser/Thr
- Core type 8 O-glycan: Galα1-3GalNAcα1-Ser/Thr
Fig.1 Biosynthesis of O-GalNAc glycans. (Zhang, et al., 2022)
We specialize in providing tailored solutions for your glycobiology research. Explore our diverse range of O-glycan structures or custom-synthesize your target structure to meet your research needs.
Applications
- Use purified O-glycans and their derivatives to study the functions and mechanisms of glycosyltransferases and glycosidases.
- Use labeled O-glycans to study the binding properties of lectins and sugars and elucidate the mechanism of sugar-protein interactions.
- Analyze abnormal O-glycan structures in diseases such as cancer to develop effective tumor vaccines and specific antibodies.
- Use specific O-glycan structures to design polysaccharide or glycopeptide vaccines to induce specific immune responses.
Advantages of Us
- We provide high-quality O-glycans to meet the needs of basic research. We also perform special modifications such as sulfation, methylation, and phosphorylation on O-glycans to support in-depth functional research.
- We use a variety of purification methods such as high-performance liquid chromatography (HPLC), ultrafiltration, and gel filtration to remove impurities and by-products to ensure that the product purity meets the research needs of clients.
- We not only provide small sizes of milligrams for the establishment of experimental methods but also provide products in grams and kilograms to meet the needs of large-scale experiments and industrialization.
A deep understanding of the structure and function of O-glycans not only helps to reveal the complex biological mechanisms in the life process but also brings unlimited possibilities for the development of new therapies and drugs. At CD BioGlyco, we always adhere to customer-oriented, continuous innovation, and jointly explore the mystery of O-glycans. If you have any needs for O-glycans, please feel free to contact us.
Reference
- Zhang, Y.; et al. A sweet warning: mucin-type O-glycans in cancer. Cells. 2022, 11(22): 3666.
