Oncogenes are overexpressed or mutated in various cancers and are one of the key factors in tumorigenesis and progression. Oncogenes are usually divided into growth factors, receptor tyrosine kinases, cytoplasmic tyrosine kinases, regulatory GTPases, and transcription factors according to their biological functions. CD BioGlyco is able to provide an analysis of the reciprocal regulation between oncogene activation and changes in glucose metabolism in cancer cells.

What We Do

Based on the MOPCGM platform, we can provide the following specific services.

• Regulatory role analysis of oncogene in glucose metabolism

Activation of oncogenes is complex and may be attributed to genetic mutations and changes in the tumor microenvironment. Studying the regulatory relationship between oncogenes and cancer cell glucose metabolism provides a lot of information for the treatment of cancer glucose metabolism.

The specific services that we can provide oncogenes to regulate glucose metabolism are as follows, including but not limited to:

• Screening of oncogenes with the regulation of glucose metabolism
• Identification of oncogene glucose metabolism-related targets
• Analysis of glucose metabolic pathways regulated by oncogenes

• Regulatory role analysis of glucose metabolism in oncogene-induced senescence

As cells undergo oncogene-induced senescence, cellular glucose metabolism undergoes dramatic changes. Many cellular senescence effectors play important roles in glucose metabolism. Currently, the characterization of glucose metabolism in malignant tumors does not distinguish whether cancer cells undergo oncogene-induced senescence. Therefore, studying the relationship between oncogene-induced senescence and glucose metabolism is helpful to fully understand the role of glucose metabolism in the whole process of tumorigenesis.

The specific services we can provide for glucose metabolism-regulated oncogene-induced senescence are as follows, including but not limited to:

• Glucose metabolism affects the assessment of oncogene-induced senescence levels
• Changes in the expression of glucose metabolism-related proteins during oncogene-induced senescence
• Changes in glucose metabolic enzyme activities during oncogene-induced senescence
• Changes in glucose metabolites during oncogene-induced senescence
• The signaling pathways involved in oncogene-induced senescence and key glucose metabolism pathways are identified

Applications

Our services can support the following applications, including but not limited to:

• To explore how cancer cells evade the growth-restricting program of cellular senescence through the regulation of glucose metabolism.
• Discovery of combined therapeutic strategies targeting oncogenes and glucose metabolism pathways.

Our Advantages

• We are able to provide a study of changes in glucose metabolism between early and advanced tumors.
• We are able to provide an analysis of glucose metabolism in cancer cells before and after oncogene-induced senescence.
• We are able to provide not only an analysis of the linear regulation between oncogene activation and cancer glucose metabolism but also an analysis of the regulatory network between the two.

CD BioGlyco can provide an analysis of oncogene activation regulating glucose metabolism in cancer cells and an analysis of glucose metabolism alterations regulating oncogene-induced senescence. Our experienced teams of scientists, researchers, and technicians provide fast turnaround, high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.