Oxidized Cellulose Analysis Service

Unlocking the Power of Oxidized Cellulose (OC): Analyzing for Safety and Efficacy

OC is a water-insoluble and acidic cellulose derivative. It contains 16% ~ 24% of carboxyl groups (COOH). OC has a wide range of applications in the medical field due to its unique acidity that triggers coagulation processes in organisms and its antibacterial properties. OC has the efficacy of anti-tumor, wound healing, immunostimulation, and prevention of adhesion. Therefore, CD BioGlyco offers detailed characterization and oxidation analysis of OC.

Conventional analysis
- Firstly, our researchers will analyze the appearance of the sample, color, pH, and osmolality.
- Identification: OC is dissolved in an aqueous solution containing sodium hydroxide. Then we observe fibers and foreign particles after mixing and after standing for 10 min, respectively. Hydrochloric acid is mixed with the tested solution to observe the formation of precipitate. We strictly follow the standards for the solution preparation and complete the record.
- Chemical content: We determine the number of carboxylic groups (COOH) in the samples through a series of services such as OC drying, setting up a control group versus a group to be tested, direct titration, and content calculations.
- Impurity test: We provide residue on ignition, nitrogen, and formaldehyde detection service through crucible burning, direct titration, and absorbance detection.
Characterization
- Our researchers characterize the structure and crystallinity of OC in detail by Raman and Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), differential scanning calorimetry (DSC), sum-frequency generation vibrational spectroscopy (SFG) and nuclear magnetic resonance (NMR).

Fig.1 Tools of OC analysis. (CD BioGlyco)

Publication Data

Technology: FTIR, Potentiometric titration, XRD

Journal: Journal of Polymer Science Part A: Polymer Chemistry

Published: 2004

Results: In this study, researchers prepared OCs with different carboxylation amounts and different crystallinity by oxidizing natural and mercerized celluose by nitrogen (IV) oxide solution in carbon tetrachloride. The advantage of this method is that the vegetated samples have low index of crystallinity (IC) and degree of polymerization (DP) and high carboxylation content. Further characterization and oxidation analysis of the obtained OCs showed that oxidation takes place only in amorphous regions and on crystal surfaces. Detailed analysis of the physicochemical properties helped to evaluate the drug binding OC properties.

Fig.2 FTIR spectra of different oxidized cellulose. (Zimnitsky, et al., 2004)

Advantages of Us

Our company has advanced tools to provide clients with comprehensive and detailed Pharmaceutical Analysis.
Our analysis team is quick to respond and help clients complete test projects quickly and accurately.
All the analyzed data are obtained through repeated testing.

CD BioGlyco provides the most appropriate analytic service for each Pharmaceutical and Biological. Depending on the molecular properties, we provide a full set of analytical services including conventional analysis, physical and chemical analysis, and biological activity analysis. Moreover, we provide Oxidized Regenerated Cellulose Analysis. Please feel free to contact us if you have additional questions about OC analysis.

References

Coseri, S.; et al. Oxidized cellulose-Survey of the most recent achievements. Carbohydrate polymers. 2013, 93(1): 207-215.
Zimnitsky, D.S.; et al. Synthesis and characterization of oxidized cellulose. Journal of Polymer Science Part A: Polymer Chemistry. 2004, 42(19): 4785-4791.

This service is for Research Use Only, not intended for any clinical use.