P-gp inhibitor LY335979, Purity ≥98%

Synonym: 167465-36-3; P-gp inhibitor; LY-335979; Zosuquidar trihydrochloride; RS-33295-198

MDL: MFCD00942300
CAS Number: 167465-36-3
Compound CID: 153997

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

LY335979, soluble in DMSO and water and insoluble in ethanol, blocks the action of P-glycoprotein, a key player in drug transport and resistance, thereby enhancing the effectiveness and bioavailability of therapeutic drugs. It targets P-gp.

Molecular Weight

637

Molecular Formula

C₃₂H₃₁F₂N₃O₂.3HCl

Targets

P-gp: 60 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 93 mg/mL (145.99 mM); Water: 21 mg/mL (32.96 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

LY335979 is a P-gp inhibitor utilized in cancer research to study its potential to overcome multidrug resistance in tumor cells.