Properties
Description
Tariquidar, soluble in DMSO and insoluble in ethanol and water, blocks the action of P-glycoprotein, a key player in drug transport and resistance, thereby enhancing the effectiveness and bioavailability of therapeutic drugs. It targets P-gp (CHrB30 cells).
Molecular Formula
C38H38N4O6
Targets
P-gp (CHrB30 cells): 5.1 nM (Kd)
Solubility
DMSO: 48 mg/mL (74.22 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Tariquidar is a P-glycoprotein (P-gp) inhibitor used in research aimed at overcoming drug resistance in cancer therapy by blocking P-gp activity.
