p38-MAPK inhibitor AMG 548, Purity ≥98%

Synonym: AMG-548; 864249-60-5; AMG 548; CHEMBL585902; PGR0H531I4; 4(3H)-Pyrimidinone, 2-(((2S)-2-amino-3-phenylpropyl)amino)-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-; 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone; p38-MAPK inhibitor

CAS Number: 864249-60-5
Compound CID: 11167112

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AMG 548 targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates.

Molecular Weight

461.56

Molecular Formula

C₂₉H₂₇N₅O

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

AMG 548 can be used to investigate the inhibition of p38α MAP kinase and its therapeutic potential in inflammation.

Storage

Store at -20ºC.