p38-MAPK inhibitor Doramapimod, Purity ≥98%

Synonym: Doramapimod; 285983-48-4; BIRB-796; BIRB 796; BIRB 796 (Doramapimod); BIRB796; BIRB-796 BS; p38-MAPK inhibitor

MDL: MFCD09752957
CAS Number: 285983-48-4
Compound CID: 156422

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Doramapimod, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38α.

Molecular Weight

527.7

Molecular Formula

C₃₁H₃₇N₅O₃

Targets

p38α: 0.1 nM (Kd); p38α: 38 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 99 mg/mL (187.61 mM); Water: Insoluble; Ethanol: 99 mg/mL (187.61 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Doramapimod can be applied to research focused on the inhibition of p38 MAP kinase in inflammatory diseases.