p38-MAPK inhibitor Doramapimod, Purity ≥98%

Synonym: Doramapimod; 285983-48-4; BIRB-796; BIRB 796; BIRB 796 (Doramapimod); BIRB796; BIRB-796 BS; p38-MAPK inhibitor

MDL: MFCD09752957
CAS Number: 285983-48-4
Compound CID: 156422

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Doramapimod, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38α.

Molecular Weight

527.7

Molecular Formula

C₃₁H₃₇N₅O₃

Targets

p38α: 0.1 nM (Kd); p38α: 38 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 99 mg/mL (187.61 mM); Water: Insoluble; Ethanol: 99 mg/mL (187.61 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Doramapimod can be applied to research focused on the inhibition of p38 MAP kinase in inflammatory diseases.

Storage

Store at -20ºC.