p38-MAPK inhibitor Losmapimod, Purity ≥98%

Synonym: Losmapimod; 585543-15-3; GSK-AHAB; GW856553; GW856553X; GW-856553; GSKAHAB; p38-MAPK inhibitor

MDL: MFCD16619322
CAS Number: 585543-15-3
Compound CID: 11552706

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Losmapimod, soluble in DMSO and warmed ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38β.

Molecular Weight

383.46

Molecular Formula

C₂₂H₂₆FN₃O₂

Targets

p38α: 8.1 (pKi); p38β: 7.6 (pKi)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 72 mg/mL (187.76 mM); Water: Insoluble; Warmed ethanol: 39 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Losmapimod is applied in research targeting the inhibition of p38 MAP kinase activity and its effects on inflammatory and cardiovascular diseases.

Storage

Store at -20ºC.