Properties
Description
LY2228820, soluble in warmed DMSO, warmed water and ethanol, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α.
Molecular Formula
C24H29FN6.2CH4O3S
Solubility
Warmed DMSO: 4 mg/mL (6.52 mM); Warmed water: 91 mg/mL (148.51 mM); Ethanol: 3 mg/mL (4.89 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
LY2228820 serves as a research tool in evaluating the inhibition of p38 MAPK alpha and beta isoforms related to inflammatory diseases and cancer.
