Properties
Description
Pamapimod, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α MAPK and p38β MAPK.
Molecular Formula
C19H20F2N4O4
Targets
p38α MAPK: 0.014 μM; p38β MAPK: 0.48 μM
Solubility
DMSO: 70 mg/mL (172.25 mM); Water: Insoluble; Ethanol: 24 mg/mL (59.06 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Pamapimod is used in studies investigating its efficacy in blocking p38 MAP kinase in the context of autoimmune and inflammatory diseases.
