p38-MAPK inhibitor Pamapimod, Purity ≥98%

Synonym: Pamapimod; 449811-01-2; RO 4402257; R1503; PamapimodR-1503; Ro4402257; Ro-4402257; p38-MAPK inhibitor

MDL: MFCD25976551
CAS Number: 449811-01-2
Compound CID: 16220188

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

MSDS

Properties

Description

Pamapimod, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α MAPK and p38β MAPK.

Molecular Weight

406.38

Molecular Formula

C₁₉H₂₀F₂N₄O₄

Targets

p38α MAPK: 0.014 μM; p38β MAPK: 0.48 μM

Form

Lyophilized powder

Purity

Solubility

DMSO: 70 mg/mL (172.25 mM); Water: Insoluble; Ethanol: 24 mg/mL (59.06 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Pamapimod is used in studies investigating its efficacy in blocking p38 MAP kinase in the context of autoimmune and inflammatory diseases.