Properties
Description
Pexmetinib, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38 MAPK and Tie-2.
Molecular Formula
C31H33FN6O3
Solubility
DMSO: 96 mg/mL (172.46 mM); Water: Insoluble; Ethanol: 96 mg/mL (172.46 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Pexmetinib can be employed to explore the dual inhibition of MEK and AXL pathways in cancer treatment.
