p38-MAPK inhibitor Pexmetinib, Purity ≥98%

Synonym: Pexmetinib; 945614-12-0; ARRY-614; Pexmetinib [INN]; Pexmetinib (ARRY-614); Pexmetinib(ARRY-614); p38-MAPK inhibitor

CAS Number: 945614-12-0
Compound CID: 24765037

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pexmetinib, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38 MAPK and Tie-2.

Molecular Weight

556.63

Molecular Formula

C₃₁H₃₃FN₆O₃

Targets

p38 MAPK; Tie-2

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 96 mg/mL (172.46 mM); Water: Insoluble; Ethanol: 96 mg/mL (172.46 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Pexmetinib can be employed to explore the dual inhibition of MEK and AXL pathways in cancer treatment.