p38-MAPK inhibitor PH-797804, Purity ≥98%

Synonym: PH-797804; 586379-66-0; PH 797804; 3-(3-Bromo-4-((2,4-difluorobenzyl)oxy)-6-methyl-2-oxopyridin-1(2H)-yl)-N,4-dimethylbenzamide; PH797804; 1358027-80-1; 3-[3-Bromo-4-[(2,4-difluorophenyl)methoxy]-6-methyl-2-oxopyridin-1-yl]-N,4-dimethylbenzamide; p38-MAPK inhibitor

CAS Number: 586379-66-0
Compound CID: 22049997

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PH-797804, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38β.

Molecular Weight

477.2

Molecular Formula

C₂₂H₁₉BrF₂N₂O₃

Targets

p38α: 26 nM; p38β: 102 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 84 mg/mL (175.99 mM); Water: Insoluble; Ethanol: 6 mg/mL (12.57 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

PH-797804 can be utilized in the investigation of p38 kinase inhibitors in the context of inflammation and cancer.