p38-MAPK inhibitor SB 202190, Purity ≥98%

Synonym: 152121-30-7; SB 202190; SB202190; SB-202190; FHPI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; p38-MAPK inhibitor

MDL: MFCD00941964
CAS Number: 152121-30-7
Compound CID: 5169

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SB 202190, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38β.

Molecular Weight

331.3

Molecular Formula

C₂₀H₁₄N₃OF

Targets

p38α: 50 nM; p38β: 100 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 62 mg/mL (187.12 mM); Water: Insoluble; Ethanol: 11 mg/mL (33.19 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

SB 202190 can be utilized to explore the role of p38 MAP kinase inhibition in inflammation and cancer.