p38-MAPK inhibitor SB 202190, Purity ≥98%

Synonym: 152121-30-7; SB 202190; SB202190; SB-202190; FHPI; 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole; p38-MAPK inhibitor

MDL: MFCD00941964
CAS Number: 152121-30-7
Compound CID: 5169

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SB 202190, soluble in DMSO and ethanol and insoluble in water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38α and p38β.

Molecular Weight

331.3

Molecular Formula

C₂₀H₁₄N₃OF

Targets

p38α: 50 nM; p38β: 100 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 62 mg/mL (187.12 mM); Water: Insoluble; Ethanol: 11 mg/mL (33.19 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SB 202190 can be utilized to explore the role of p38 MAP kinase inhibition in inflammation and cancer.

Storage

Store at -20ºC.