p38-MAPK inhibitor SB 203580, Purity ≥98%

Synonym: 152121-47-6; SB 203580; SB-203580; SB203580; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole; Adezmapimod; 4-[4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; p38-MAPK inhibitor

MDL: MFCD00922198
CAS Number: 152121-47-6
Compound CID: 176155

Product Size

25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SB 203580, soluble in DMSO and insoluble in ethanol and water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38 MAPK (THP-1 cells) and PKB (THP-1 cells).

Molecular Weight

377.4

Molecular Formula

C₂₁H₁₆FN₃OS

Targets

p38 MAPK (THP-1 cells): 0.3-0.5 μM; PKB (THP-1 cells): 3-5 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 40 mg/mL (105.97 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

SB 203580 can be used to study the inhibition of p38 MAP kinase and its effects on cellular stress response.