p38-MAPK inhibitor SB 203580, Purity ≥98%

Synonym: 152121-47-6; SB 203580; SB-203580; SB203580; 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole; Adezmapimod; 4-[4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; p38-MAPK inhibitor

MDL: MFCD00922198
CAS Number: 152121-47-6
Compound CID: 176155

Product Size

25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SB 203580, soluble in DMSO and insoluble in ethanol and water, targets the ATP-binding site of the kinase, thereby preventing phosphorylation of downstream substrates. It targets p38 MAPK (THP-1 cells) and PKB (THP-1 cells).

Molecular Weight

377.4

Molecular Formula

C₂₁H₁₆FN₃OS

Targets

p38 MAPK (THP-1 cells): 0.3-0.5 μM; PKB (THP-1 cells): 3-5 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 40 mg/mL (105.97 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SB 203580 can be used to study the inhibition of p38 MAP kinase and its effects on cellular stress response.

Storage

Store at -20ºC.